Endothelial nitric oxide synthase deficiency produces accelerated nephropathy in diabetic mice
HJ Zhao, S Wang, H Cheng, M Zhang… - Journal of the …, 2006 - journals.lww.com
Functionally significant polymorphisms in endothelial nitric oxide synthase (eNOS) and
reduced vascular eNOS activity have been associated with increased human diabetic
nephropathy (DN), but the pathogenic role of eNOS deficiency in the development of DN has
not yet been confirmed. This study characterizes the severity of DN in eNOS−/− mice that
were backcrossed to C57BLKS/J db/db mice. Although the severity of hyperglycemia was
similar to C57BLKS/J db/db mice, by 26 wk, eNOS−/− C57BLKS/J db/db mice exhibited …
reduced vascular eNOS activity have been associated with increased human diabetic
nephropathy (DN), but the pathogenic role of eNOS deficiency in the development of DN has
not yet been confirmed. This study characterizes the severity of DN in eNOS−/− mice that
were backcrossed to C57BLKS/J db/db mice. Although the severity of hyperglycemia was
similar to C57BLKS/J db/db mice, by 26 wk, eNOS−/− C57BLKS/J db/db mice exhibited …