SEPT5_v2 is a parkin-binding protein
P Choi, H Snyder, L Petrucelli, C Theisler… - Molecular Brain …, 2003 - Elsevier
Mutations in parkin are associated with various inherited forms of Parkinson's disease (PD).
Parkin is a ubiquitin ligase enzyme that catalyzes the covalent attachment of ubiquitin
moieties onto substrate proteins destined for proteasomal degradation. The substrates of
parkin-mediated ubiquitination have yet to be completely identified. Using a yeast two-hybrid
screen, we isolated the septin, human SEPT5_v2 (also known as cell division control-related
protein 2), as a putative parkin-binding protein. SEPT5_v2 is highly homologous to another …
Parkin is a ubiquitin ligase enzyme that catalyzes the covalent attachment of ubiquitin
moieties onto substrate proteins destined for proteasomal degradation. The substrates of
parkin-mediated ubiquitination have yet to be completely identified. Using a yeast two-hybrid
screen, we isolated the septin, human SEPT5_v2 (also known as cell division control-related
protein 2), as a putative parkin-binding protein. SEPT5_v2 is highly homologous to another …