[HTML][HTML] Silent mutations in KIT and PDGFRA and coexpression of receptors with SCF and PDGFA in Merkel cell carcinoma: implications for tyrosine kinase-based …
RV Kartha, UN Sundram - Modern Pathology, 2008 - Elsevier
Merkel cell carcinoma is a rare and aggressive form of skin cancer of neuroendocrine origin.
Its treatment involves wide excision and radiotherapy but no effective therapy exists for
advanced disease. Upregulation of the platelet-derived growth factor receptor family of
tyrosine kinases, PDGFRA and KIT, has a crucial role in cancer development. Several
studies have shown expression of the tyrosine kinase receptor KIT (CD117) in Merkel cell
carcinoma. In this study, we examined the expression and mutational status of KIT and …
Its treatment involves wide excision and radiotherapy but no effective therapy exists for
advanced disease. Upregulation of the platelet-derived growth factor receptor family of
tyrosine kinases, PDGFRA and KIT, has a crucial role in cancer development. Several
studies have shown expression of the tyrosine kinase receptor KIT (CD117) in Merkel cell
carcinoma. In this study, we examined the expression and mutational status of KIT and …