Transmissible murine colonic hyperplasia

SW Barthold, GL Coleman, RO Jacoby… - Veterinary …, 1978 - journals.sagepub.com
SW Barthold, GL Coleman, RO Jacoby, EM Livstone, AM Jonas
Veterinary pathology, 1978journals.sagepub.com
After exposure to a variant of Citrobacter freundii, suckling and adult mice developed
transmissible murine colonic hyperplasia of the same degree of severity. Mucosal
hyperplasia was most severe 2 to 3 weeks after inoculation and then regressed. Suckling
mice had a high mortality because of secondary inflammatory and erosive changes. Severe
hyperplasia was characterized by mitotic activity along the entire crypt column and surface
mucosa.
After exposure to a variant of Citrobacter freundii, suckling and adult mice developed transmissible murine colonic hyperplasia of the same degree of severity. Mucosal hyperplasia was most severe 2 to 3 weeks after inoculation and then regressed. Suckling mice had a high mortality because of secondary inflammatory and erosive changes. Severe hyperplasia was characterized by mitotic activity along the entire crypt column and surface mucosa.
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