[HTML][HTML] Down-regulation of RNA editing in pediatric astrocytomas: ADAR2 editing activity inhibits cell migration and proliferation
C Cenci, R Barzotti, F Galeano, S Corbelli… - Journal of Biological …, 2008 - ASBMB
Since alterations in post-transcriptional events can contribute to the appearance and/or
progression of cancer, we investigated whether RNA editing, catalyzed by the ADAR
(adenosine deaminases that act on RNA) enzymes, is altered in pediatric astrocytomas. We
find a decrease in ADAR2 editing activity that seems to correlate with the grade of
malignancy in children. Despite the loss of ADAR2 editing activity in tumor tissues, the high
grade astrocytomas do not exhibit alterations in ADAR2 expression when compared with …
progression of cancer, we investigated whether RNA editing, catalyzed by the ADAR
(adenosine deaminases that act on RNA) enzymes, is altered in pediatric astrocytomas. We
find a decrease in ADAR2 editing activity that seems to correlate with the grade of
malignancy in children. Despite the loss of ADAR2 editing activity in tumor tissues, the high
grade astrocytomas do not exhibit alterations in ADAR2 expression when compared with …