Defining a genomic radius for long-range enhancer action: duplicated conserved non-coding elements hold the key
Many conserved non-coding elements (CNEs) in vertebrate genomes have been shown to
function as tissue-specific enhancers. However, the target genes of most CNEs are
unknown. Here we show that the target genes of duplicated CNEs can be predicted by
considering their neighbouring paralogous genes. This enables us to provide the first
systematic estimate of the genomic range for distal cis-regulatory interactions in the human
genome: half of CNEs are> 250kb away from their associated gene.
function as tissue-specific enhancers. However, the target genes of most CNEs are
unknown. Here we show that the target genes of duplicated CNEs can be predicted by
considering their neighbouring paralogous genes. This enables us to provide the first
systematic estimate of the genomic range for distal cis-regulatory interactions in the human
genome: half of CNEs are> 250kb away from their associated gene.
Many conserved non-coding elements (CNEs) in vertebrate genomes have been shown to function as tissue-specific enhancers. However, the target genes of most CNEs are unknown. Here we show that the target genes of duplicated CNEs can be predicted by considering their neighbouring paralogous genes. This enables us to provide the first systematic estimate of the genomic range for distal cis-regulatory interactions in the human genome: half of CNEs are >250kb away from their associated gene.
cell.com