Age-related macular degeneration
EK de Jong, MJ Geerlings, AI den Hollander - Genetics and genomics of …, 2020 - Elsevier
Age-related macular degeneration (AMD) is a multifactorial disease influenced by a
combination of environmental factors and genetic variants. Genomic studies have been
exceptionally successful in AMD and have identified a significant proportion of the
heritability. In this chapter, we provide an overview of genomic studies in AMD, focusing on
different approaches that have been used to identify common and rare variants associated
with the disease. In addition, we evaluate the effect of AMD-associated genetic variants on …
combination of environmental factors and genetic variants. Genomic studies have been
exceptionally successful in AMD and have identified a significant proportion of the
heritability. In this chapter, we provide an overview of genomic studies in AMD, focusing on
different approaches that have been used to identify common and rare variants associated
with the disease. In addition, we evaluate the effect of AMD-associated genetic variants on …
Age-related macular degeneration histopathologic studies: the 1992 Lorenz E. Zimmerman Lecture
WR Green, C Enger - Retina, 2005 - journals.lww.com
Background: Delineation qf the morphologic aspects of age-related macular degeneration
(ARMD) is helpful in correlation with the clinical features and may contribute to
understanding the pathogenesis. Methods: All eyes on file in the Eye Pathology Laboratory,
Wilmer lnstitute, with the known features of ARMD were analyzed according to age, sex, and
race. Methods included routine sections in the macula, stepped-serial and serial sections,
and electron microscopy and two-dimensional reconstruction in selected cases. Results …
(ARMD) is helpful in correlation with the clinical features and may contribute to
understanding the pathogenesis. Methods: All eyes on file in the Eye Pathology Laboratory,
Wilmer lnstitute, with the known features of ARMD were analyzed according to age, sex, and
race. Methods included routine sections in the macula, stepped-serial and serial sections,
and electron microscopy and two-dimensional reconstruction in selected cases. Results …