Enhancement of dendritic cell-based vaccine potency by anti-apoptotic siRNAs targeting key pro-apoptotic proteins in cytotoxic CD8+ T cell-mediated cell death
JH Kim, TH Kang, KH Noh, HC Bae, SH Kim… - Immunology letters, 2009 - Elsevier
Dendritic cells (DCs) have become an important measure for the treatment of malignancies.
Current DC preparations, however, generate short-lived DCs because they are subject to
cell death from various apoptotic pressures. Antigen-specific CD8+ cytotoxic T lymphocytes
(CTLs) is one of the main obstacles to limit the DC-mediated immune priming since CTLs
can recognize the target antigen expressing DCs as target cells and kill the DCs. CTLs
secret perforin and serine protease granzymes during CTL killing. Perforin and serine …
Current DC preparations, however, generate short-lived DCs because they are subject to
cell death from various apoptotic pressures. Antigen-specific CD8+ cytotoxic T lymphocytes
(CTLs) is one of the main obstacles to limit the DC-mediated immune priming since CTLs
can recognize the target antigen expressing DCs as target cells and kill the DCs. CTLs
secret perforin and serine protease granzymes during CTL killing. Perforin and serine …