The challenge of continuous exogenous glucocorticoid administration in mice
M Herrmann, H Henneicke, J Street, J Modzelewski… - Steroids, 2009 - Elsevier
BACKGROUND: Chronic administration of exogenous glucocorticoids is often required in
experimental research. We compared the efficacy and reliability of three different methods of
continuous glucocorticoid administration in mice. MATERIALS AND METHODS: Male CD1
Swiss White mice aged 7–9 weeks received corticosterone (CS) or carrier by either
subcutaneous (sc) injection (n= 15), sc implantation of micro-osmotic pumps (n= 20) or sc
implantation of slow-release pellets (n= 20). Serial blood samples were taken for the …
experimental research. We compared the efficacy and reliability of three different methods of
continuous glucocorticoid administration in mice. MATERIALS AND METHODS: Male CD1
Swiss White mice aged 7–9 weeks received corticosterone (CS) or carrier by either
subcutaneous (sc) injection (n= 15), sc implantation of micro-osmotic pumps (n= 20) or sc
implantation of slow-release pellets (n= 20). Serial blood samples were taken for the …