Response of serum carboxylated and undercarboxylated osteocalcin to risedronate monotherapy and combined therapy with vitamin K2 in corticosteroid-treated …
T Hozuki, T Imai, E Tsuda, A Matsumura… - Internal …, 2010 - jstage.jst.go.jp
T Hozuki, T Imai, E Tsuda, A Matsumura, D Yamamoto, T Toyoshima, S Suzuki, R Yamauchi…
Internal Medicine, 2010•jstage.jst.go.jpObjective The aim of this study was to investigate the responses of serum osteocalcin (OC),
undercarboxylated osteocalcin (ucOC) and N-terminal telopeptide of type I collagen (NTx) to
corticosteroids, and to examine the effects of risedronate therapy with or without vitamin K 2
supplementation on bone metabolic markers in corticosteroid-treated patients. Methods
Sixteen patients on corticosteroid therapy for neuromuscular disorders were assigned
randomly to 2 groups (A: risedronate monotherapy, n= 8; B: combined risedronate and …
undercarboxylated osteocalcin (ucOC) and N-terminal telopeptide of type I collagen (NTx) to
corticosteroids, and to examine the effects of risedronate therapy with or without vitamin K 2
supplementation on bone metabolic markers in corticosteroid-treated patients. Methods
Sixteen patients on corticosteroid therapy for neuromuscular disorders were assigned
randomly to 2 groups (A: risedronate monotherapy, n= 8; B: combined risedronate and …
抄録
Objective The aim of this study was to investigate the responses of serum osteocalcin (OC), undercarboxylated osteocalcin (ucOC) and N-terminal telopeptide of type I collagen (NTx) to corticosteroids, and to examine the effects of risedronate therapy with or without vitamin K 2 supplementation on bone metabolic markers in corticosteroid-treated patients.
Methods Sixteen patients on corticosteroid therapy for neuromuscular disorders were assigned randomly to 2 groups (A: risedronate monotherapy, n= 8; B: combined risedronate and vitamin K 2 therapy, n= 8) and treated for 1 year. Another 6 patients who received intravenous steroid pulse therapy were assigned to group C for investigation of the effects of corticosteroids on OC and ucOC 1 month after pulse therapy.
Results Serial measurements revealed that significant decreases of OC, ucOC and NTx persisted with a similar time course profile during 1 year of treatment in groups A and B, and between-group analysis failed to demonstrate any additional effects of vitamin K 2 on risedronate therapy. Intravenous steroid pulse therapy induced a transient depression of OC and ucOC within 1 week in group C.
Conclusion These results indicate that serum concentrations of OC and ucOC become consistently low during corticosteroid administration despite risedronate therapy with or without vitamin K 2 supplementation, and the serum ucOC level may not be a reliable indicator of vitamin K status under corticosteroid administration.
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