[HTML][HTML] A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins

TH Davies, YM Ning, ER Sánchez - Journal of Biological Chemistry, 2002 - ASBMB
We have identified a new first step in the hormonal activation of the glucocorticoid receptor
(GR). Rather than causing immediate dissociation of the cytoplasmic GR heterocomplex,
binding of hormone-induced substitution of one immunophilin (FKBP51) for another
(FKBP52), and concomitant recruitment of the transport protein dynein while leaving Hsp90
unchanged. Immunofluorescence and fractionation revealed hormone-induced translocation
of the hormone-generated GR· Hsp90· FKBP52· dynein complex from cytoplasm to nucleus …