The innate immune system is an evolutionarily highly conserved first rapid line of host
defense against tissue injury and consists of a whole family of mobile and sessile cells such
as antigen-presenting cells, innate lymphocytes, neutrophils, and vascular cells—dendritic
cells representing the bridge to development of an adaptive immune response. The system
depends on molecules collectively known as pattern recognition receptors to survey the
extracellular space and the cytoplasm for the presence of exogenous pathogen-associated …