Dendritic cells and macrophages are critical early initiators of innate immunity in the kidney
and orchestrate inflammation subsequent to ischemia-reperfusion injury. They are the most
abundant leukocytes present in the kidney, and they represent a heterogeneous population
of cells that are capable of inducing sterile inflammation after reperfusion directly through the
production of proinflammatory cytokines and other soluble inflammatory mediators or
indirectly through activation of effector T lymphocytes and natural killer T cells. In addition …