4-Aminopyridine restores impaired hypoxic pulmonary vasoconstriction in endotoxemic mice
F Spöhr, CJ Busch, C Reich, J Motsch… - The Journal of the …, 2007 - pubs.asahq.org
Background Hypoxic pulmonary vasoconstriction (HPV) is impaired during inflammatory
lung processes such as pneumonia or the acute respiratory distress syndrome. Voltage-
gated potassium channels play a central role in mediating HPV. The aim of this study was to
determine whether 4-aminopyridine (4-AP), a known voltage-gated potassium channel
inhibitor, may restore HPV in sepsis. Methods The effects of 0.01, 0.1, and 1.0 mm 4-AP on
HPV responsiveness were assessed in isolated lungs of untreated mice and of mice 18 h …
lung processes such as pneumonia or the acute respiratory distress syndrome. Voltage-
gated potassium channels play a central role in mediating HPV. The aim of this study was to
determine whether 4-aminopyridine (4-AP), a known voltage-gated potassium channel
inhibitor, may restore HPV in sepsis. Methods The effects of 0.01, 0.1, and 1.0 mm 4-AP on
HPV responsiveness were assessed in isolated lungs of untreated mice and of mice 18 h …