[HTML][HTML] Calcium-mediated Translocation of Cytosolic Phospholipase A2 to the Nuclear Envelope and Endoplasmic Reticulum (∗)
AR Schievella, MK Regier, WL Smith, LL Lin - Journal of Biological …, 1995 - ASBMB
Cytosolic phospholipase A 2 (cPLA 2) is activated by a wide variety of stimuli to release
arachidonic acid, the precursor of the potent inflammatory mediators prostaglandin and
leukotriene. Specifically, cPLA 2 releases arachidonic acid in response to agents that
increase intracellular Ca 2+. In vitro data have suggested that these agents induce a
translocation of cPLA 2 from the cytosol to the cell membrane, where its substrate is
localized. Here, we use immunofluorescence to visualize the translocation of cPLA 2 to …
arachidonic acid, the precursor of the potent inflammatory mediators prostaglandin and
leukotriene. Specifically, cPLA 2 releases arachidonic acid in response to agents that
increase intracellular Ca 2+. In vitro data have suggested that these agents induce a
translocation of cPLA 2 from the cytosol to the cell membrane, where its substrate is
localized. Here, we use immunofluorescence to visualize the translocation of cPLA 2 to …