[HTML][HTML] Regulation of purified and reconstituted connexin 43 hemichannels by protein kinase C-mediated phosphorylation of Serine 368
X Bao, L Reuss, GA Altenberg - Journal of Biological Chemistry, 2004 - ASBMB
Indirect evidence suggests that the permeability of connexin 43 (Cx43) gap-junctional
channels (connexons) to small organic molecules (M r< 1,000) is decreased by protein
kinase C (PKC)-mediated phosphorylation of Ser-368. However, it is currently unknown
whether this effect is produced directly by phosphorylation of this residue or whether
cytoplasmic regulatory factors are required for the decrease in Cx43 gap-junctional channel
permeability. Here we studied the effects of PKC-mediated phosphorylation on purified …
channels (connexons) to small organic molecules (M r< 1,000) is decreased by protein
kinase C (PKC)-mediated phosphorylation of Ser-368. However, it is currently unknown
whether this effect is produced directly by phosphorylation of this residue or whether
cytoplasmic regulatory factors are required for the decrease in Cx43 gap-junctional channel
permeability. Here we studied the effects of PKC-mediated phosphorylation on purified …