IL-9 is associated with an impaired Th1 immune response in patients with tuberculosis
B Wu, C Huang, M Kato-Maeda, PC Hopewell… - Clinical …, 2008 - Elsevier
Although a defective Th1 response has been demonstrated in patients infected with
Mycobacterium tuberculosis (Mtb), the mechanisms leading to this defect are not well
understood. To study the immune response to Mtb infection, we stimulated PBMC from
individuals with latent tuberculosis infection (LTBI) or patients with tuberculosis (TB) with the
Mtb specific antigen early secretory antigenic target-6 (ESAT-6). mRNAs for a panel of
cytokines were measured using quantitative real-time PCR (qPCR). PBMC from TB patients …
Mycobacterium tuberculosis (Mtb), the mechanisms leading to this defect are not well
understood. To study the immune response to Mtb infection, we stimulated PBMC from
individuals with latent tuberculosis infection (LTBI) or patients with tuberculosis (TB) with the
Mtb specific antigen early secretory antigenic target-6 (ESAT-6). mRNAs for a panel of
cytokines were measured using quantitative real-time PCR (qPCR). PBMC from TB patients …