[PDF][PDF] MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome
Y Cámara, J Asin-Cayuela, CB Park, MD Metodiev… - Cell metabolism, 2011 - cell.com
Cell metabolism, 2011•cell.com
Precise control of mitochondrial DNA gene expression is critical for regulation of oxidative
phosphorylation capacity in mammals. The MTERF protein family plays a key role in this
process, and its members have been implicated in regulation of transcription initiation and
site-specific transcription termination. We now demonstrate that a member of this family,
MTERF4, directly controls mitochondrial ribosomal biogenesis and translation. MTERF4
forms a stoichiometric complex with the ribosomal RNA methyltransferase NSUN4 and is …
phosphorylation capacity in mammals. The MTERF protein family plays a key role in this
process, and its members have been implicated in regulation of transcription initiation and
site-specific transcription termination. We now demonstrate that a member of this family,
MTERF4, directly controls mitochondrial ribosomal biogenesis and translation. MTERF4
forms a stoichiometric complex with the ribosomal RNA methyltransferase NSUN4 and is …
Summary
Precise control of mitochondrial DNA gene expression is critical for regulation of oxidative phosphorylation capacity in mammals. The MTERF protein family plays a key role in this process, and its members have been implicated in regulation of transcription initiation and site-specific transcription termination. We now demonstrate that a member of this family, MTERF4, directly controls mitochondrial ribosomal biogenesis and translation. MTERF4 forms a stoichiometric complex with the ribosomal RNA methyltransferase NSUN4 and is necessary for recruitment of this factor to the large ribosomal subunit. Loss of MTERF4 leads to defective ribosomal assembly and a drastic reduction in translation. Our results thus show that MTERF4 is an important regulator of translation in mammalian mitochondria.
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