Inflammation in the early stages of neurodegenerative pathology

PJ Khandelwal, AM Herman, CEH Moussa - Journal of neuroimmunology, 2011 - Elsevier
Inflammation is secondary to protein accumulation in neurodegenerative diseases, including
Alzheimer's, Parkinson's and Amyotrophic Lateral Sclerosis. Emerging evidence indicate
sustained inflammatory responses, involving microglia and astrocytes in animal models of
neurodegeneration. It is unknown whether inflammation is beneficial or detrimental to
disease progression and how inflammatory responses are induced within the CNS.
Persistence of an inflammatory stimulus or failure to resolve sustained inflammation can …