Inflammation-mediated upregulation of centrosomal protein 110, a negative modulator of ciliogenesis, in patients with chronic rhinosinusitis
Y Lai, B Chen, J Shi, JN Palmer, DW Kennedy… - Journal of allergy and …, 2011 - Elsevier
BACKGROUND: Sinonasal mucosa in patients with chronic rhinosinusitis (CRS) is often
devoid of motile cilia. This defect is presumed to result from prolonged inflammation,
infection, or both. However, the mechanism underlying this observation is unknown.
Recently, centrosomal protein 110 (Cp110) was shown to prevent the terminal step in ciliary
maturation (ie, elongation), suggesting that Cp110 might be involved in pathological states
in which ciliation is abnormal. OBJECTIVES: First, we sought to investigate the expression of …
devoid of motile cilia. This defect is presumed to result from prolonged inflammation,
infection, or both. However, the mechanism underlying this observation is unknown.
Recently, centrosomal protein 110 (Cp110) was shown to prevent the terminal step in ciliary
maturation (ie, elongation), suggesting that Cp110 might be involved in pathological states
in which ciliation is abnormal. OBJECTIVES: First, we sought to investigate the expression of …