Chronic rhinosinusitis (CRS), affecting more than 35 million Americans of all ages, 1
represents several distinct entities which are clinically indistinguishable. Although the
mortality of the disease is low, the morbidity is high, with CRS patients demonstrating worse
quality-of-life scores for physical pain and social functioning than those suffering from
chronic obstructive pulmonary disease, congestive heart failure, or angina. 2 Multiple
causes contribute to the development of CRS, but a common pathophysiologic sequela is …