BCL-6 regulates chemokine gene transcription in macrophages

LM Toney, G Cattoretti, JA Graf, T Merghoub… - Nature …, 2000 - nature.com
LM Toney, G Cattoretti, JA Graf, T Merghoub, PP Pandolfi, R Dalla-Favera, BH Ye, AL Dent
Nature immunology, 2000nature.com
The transcriptional repressor protein BCL-6, implicated in the pathogenesis of B cell
lymphoma, regulates lymphocyte differentiation and inflammation. We investigated the
mechanism for the T helper cell subset 2 (TH 2)-type inflammation that occurs in BCL-6−/−
mice. Using chimeric mice we found that the TH 2-type inflammation is dependent upon
nonlymphoid cells. We identified three chemokines, MCP-1, MCP-3 and MRP-1, which are
negatively regulated by BCL-6 in macrophages. Promoter analysis revealed that BCL-6 is a …
Abstract
The transcriptional repressor protein BCL-6, implicated in the pathogenesis of B cell lymphoma, regulates lymphocyte differentiation and inflammation. We investigated the mechanism for the T helper cell subset 2 (T H 2)-type inflammation that occurs in BCL-6−/− mice. Using chimeric mice we found that the T H 2-type inflammation is dependent upon nonlymphoid cells. We identified three chemokines, MCP-1, MCP-3 and MRP-1, which are negatively regulated by BCL-6 in macrophages. Promoter analysis revealed that BCL-6 is a potent repressor of MCP-1 transcription. Our results provide a mechanism for the regulation of T H 2-type inflammation by BCL-6 and link T H 2 differentiation to innate immunity.
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