[HTML][HTML] A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity
S Sookoian, GO Castaño, AL Burgueño… - Journal of lipid …, 2009 - ASBMB
We explored the role of the adiponutrin (PNPLA3) nonsynonymous-rs738409 single
nucleotide polymorphism (SNP) in genetic susceptibility to nonalcoholic fatty liver disease
(NAFLD) and whether this SNP contributes to the severity of histological disease. Two
hundred sixty-six individuals were evaluated in a case-control association study, which
included 172 patients with features of NAFLD and 94 control subjects. The rs738409 G
allele was significantly associated with NAFLD (P< 0.001; OR 2.8 95%, CI 1.5–5.2) …
nucleotide polymorphism (SNP) in genetic susceptibility to nonalcoholic fatty liver disease
(NAFLD) and whether this SNP contributes to the severity of histological disease. Two
hundred sixty-six individuals were evaluated in a case-control association study, which
included 172 patients with features of NAFLD and 94 control subjects. The rs738409 G
allele was significantly associated with NAFLD (P< 0.001; OR 2.8 95%, CI 1.5–5.2) …