PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese individuals
MA Burza, C Pirazzi, C Maglio, K Sjöholm… - Digestive and Liver …, 2012 - Elsevier
BACKGROUND: Obesity is a risk factor for cancer, including hepatocellular carcinoma.
Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) genetic
variant has been associated with hepatocellular carcinoma (HCC) in individuals with chronic
alcohol abuse or hepatic viral infection. In the present study we examined the association
between the PNPLA3 I148M genetic variant and hepatocellular carcinoma in obese
individuals from the Swedish Obese Subjects cohort (n= 4047). METHODS: We performed a …
Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) genetic
variant has been associated with hepatocellular carcinoma (HCC) in individuals with chronic
alcohol abuse or hepatic viral infection. In the present study we examined the association
between the PNPLA3 I148M genetic variant and hepatocellular carcinoma in obese
individuals from the Swedish Obese Subjects cohort (n= 4047). METHODS: We performed a …
