Hematopoietic niche and bone meet
BJ Frisch, RL Porter, LM Calvi - Current opinion in supportive and …, 2008 - journals.lww.com
BJ Frisch, RL Porter, LM Calvi
Current opinion in supportive and palliative care, 2008•journals.lww.comThe HSC niche comprises complex interactions between multiple cell types and molecules
requiring cell–cell signaling as well as local secretion. These components can be thought of
as therapeutic targets not only for HSC expansion, but also to modify behavior of
hematopoietic malignancies and cancer metastases to the bone.
requiring cell–cell signaling as well as local secretion. These components can be thought of
as therapeutic targets not only for HSC expansion, but also to modify behavior of
hematopoietic malignancies and cancer metastases to the bone.
Summary
The HSC niche comprises complex interactions between multiple cell types and molecules requiring cell–cell signaling as well as local secretion. These components can be thought of as therapeutic targets not only for HSC expansion, but also to modify behavior of hematopoietic malignancies and cancer metastases to the bone.
Lippincott Williams & Wilkins