[HTML][HTML] Clonal analyses define the relationships between chromosomal abnormalities and JAK2V617F in patients with Ph-negative myeloproliferative neoplasms
X Wang, A LeBlanc, S Gruenstein, M Xu… - Experimental …, 2009 - Elsevier
OBJECTIVE: JAK2V617F occurs in∼ 93% of patients with polycythemia vera and∼ 50% of
patients with either primary myelofibrosis or essential thrombocythemia. Chromosomal
abnormalities are detected in 50% of patients with primary myelofibrosis, 29% with
polycythemia vera, and 8% to 10% with essential thrombocythemia. The relationship
between the presence of such chromosomal abnormalities and the JAK2V617 allele burden,
and the role that each of these genetic events play in the origins and progression of the …
patients with either primary myelofibrosis or essential thrombocythemia. Chromosomal
abnormalities are detected in 50% of patients with primary myelofibrosis, 29% with
polycythemia vera, and 8% to 10% with essential thrombocythemia. The relationship
between the presence of such chromosomal abnormalities and the JAK2V617 allele burden,
and the role that each of these genetic events play in the origins and progression of the …