Effects of a high saturated fat diet on cardiac hypertrophy and dysfunction in response to pressure overload
DJ Chess, B Lei, BD Hoit, AM Azimzadeh… - Journal of cardiac …, 2008 - Elsevier
BACKGROUND: Dietary lipid content effects activation of peroxisome proliferator-activated
receptor-α (PPAR-α) and may accelerate cardiac hypertrophy and dysfunction in response
to pressure overload. This study investigated the effects of a high-fat diet on the
development of cardiac hypertrophy. METHODS AND RESULTS: C57BL/6J mice (n= 14–
16/group) underwent transverse aortic constriction (TAC) or sham surgery and were fed
either standard low-fat diet (STD; 10% fat) or a high-fat diet (HFD; 60% fat) for 16 weeks …
receptor-α (PPAR-α) and may accelerate cardiac hypertrophy and dysfunction in response
to pressure overload. This study investigated the effects of a high-fat diet on the
development of cardiac hypertrophy. METHODS AND RESULTS: C57BL/6J mice (n= 14–
16/group) underwent transverse aortic constriction (TAC) or sham surgery and were fed
either standard low-fat diet (STD; 10% fat) or a high-fat diet (HFD; 60% fat) for 16 weeks …