[HTML][HTML] The tuberin-hamartin complex negatively regulates β-catenin signaling activity
BC Mak, KI Takemaru, HL Kenerson, RT Moon… - Journal of Biological …, 2003 - ASBMB
Tuberous sclerosis complex (TSC) is characterized by the formation of hamartomas in
multiple organs resulting from mutations in the TSC1 or TSC2 gene. Their protein products,
hamartin and tuberin, respectively, form a functional complex that affects cell growth,
differentiation, and proliferation. Several lines of evidence, including renal tumors derived
from TSC2+/− animals, suggest that the loss or inhibition of tuberin is associated with up-
regulation of cyclin D1. As cyclin D1 can be regulated through the canonical Wnt/β-catenin …
multiple organs resulting from mutations in the TSC1 or TSC2 gene. Their protein products,
hamartin and tuberin, respectively, form a functional complex that affects cell growth,
differentiation, and proliferation. Several lines of evidence, including renal tumors derived
from TSC2+/− animals, suggest that the loss or inhibition of tuberin is associated with up-
regulation of cyclin D1. As cyclin D1 can be regulated through the canonical Wnt/β-catenin …