Lymphangiogenesis in lymphangioleiomyomatosis: its implication in the progression of lymphangioleiomyomatosis
T Kumasaka, K Seyama, K Mitani, T Sato… - The American journal …, 2004 - journals.lww.com
Lymphangioleiomyomatosis (LAM) is characterized by the proliferation of abnormal smooth
muscle cells (LAM cells) in the lungs, lymph nodes, and/or other organs. We examined
lymphangiogenesis using immunohistochemistry for Flt-4 (VEGFR-3), a new specific marker
for lymphatic endothelial cells, as well as the expression of vascular endothelial growth
factor (VEGF)-C in LAM. Specimens were obtained from 6 autopsy cases, a single lung
transplant case, and 8 surgical cases for analyses. We demonstrated that lymphatics were …
muscle cells (LAM cells) in the lungs, lymph nodes, and/or other organs. We examined
lymphangiogenesis using immunohistochemistry for Flt-4 (VEGFR-3), a new specific marker
for lymphatic endothelial cells, as well as the expression of vascular endothelial growth
factor (VEGF)-C in LAM. Specimens were obtained from 6 autopsy cases, a single lung
transplant case, and 8 surgical cases for analyses. We demonstrated that lymphatics were …