Immunohistochemical study of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in pulmonary lymphangioleiomyomatosis (LAM)
T Hayashi, MV Fleming, WG Stetler-Stevenson… - Human pathology, 1997 - Elsevier
To evaluate the role of matrix metalloproteinases (MMPs) and their specific tissue inhibitors
(TIMPs) in the pathogenesis of the structural damage and cystic lesions found in pulmonary
lymphangioleiomyomatosis (LAM), immunohistochemical studies were made of the
localization of MMP-1, MMP-2, MMP-3, MMP-9, TIMP-1, TIMP2, HMB-45, and type IV
collagen in sections of lung biopsy specimens from four patients with this disorder. These
studies showed increased immunoreactivity compared with that in normal bronchiolar and …
(TIMPs) in the pathogenesis of the structural damage and cystic lesions found in pulmonary
lymphangioleiomyomatosis (LAM), immunohistochemical studies were made of the
localization of MMP-1, MMP-2, MMP-3, MMP-9, TIMP-1, TIMP2, HMB-45, and type IV
collagen in sections of lung biopsy specimens from four patients with this disorder. These
studies showed increased immunoreactivity compared with that in normal bronchiolar and …