High incidence of head and neck squamous cell carcinoma in patients with Fanconi anemia
DI Kutler, AD Auerbach, J Satagopan… - … –head & neck …, 2003 - jamanetwork.com
Background Fanconi anemia (FA) is a rare autosomal recessive disorder characterized by a
high degree of genomic instability and predisposition to cancer development. Recent
evidence suggests that the incidence of head and neck squamous cell carcinoma (HNSCC)
may be increased in patients with FA. Objective To determine the cumulative incidence,
tumor distribution, and outcome of HNSCC in patients with FA. Design and Setting We
analyzed data from 754 subjects from the International Fanconi Anemia Registry, a …
high degree of genomic instability and predisposition to cancer development. Recent
evidence suggests that the incidence of head and neck squamous cell carcinoma (HNSCC)
may be increased in patients with FA. Objective To determine the cumulative incidence,
tumor distribution, and outcome of HNSCC in patients with FA. Design and Setting We
analyzed data from 754 subjects from the International Fanconi Anemia Registry, a …