Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury: results of the third national acute …
MB Bracken, MJ Shepard, TR Holford, L Leo-Summers… - Jama, 1997 - jamanetwork.com
Objective.—To compare the efficacy of methylprednisolone administered for 24 hours with
methyprednisolone administered for 48 hours or tirilazad mesylate administered for 48
hours in patients with acute spinal cord injury. Design.—Double-blind, randomized clinical
trial. Setting.—Sixteen acute spinal cord injury centers in North America. Patients.—A total of
499 patients with acute spinal cord injury diagnosed in National Acute Spinal Cord Injury
Study (NASCIS) centers within 8 hours of injury. Intervention.—All patients received an …
methyprednisolone administered for 48 hours or tirilazad mesylate administered for 48
hours in patients with acute spinal cord injury. Design.—Double-blind, randomized clinical
trial. Setting.—Sixteen acute spinal cord injury centers in North America. Patients.—A total of
499 patients with acute spinal cord injury diagnosed in National Acute Spinal Cord Injury
Study (NASCIS) centers within 8 hours of injury. Intervention.—All patients received an …