Immune response to biologic scaffold materials

SF Badylak, TW Gilbert - Seminars in immunology, 2008 - Elsevier
Seminars in immunology, 2008Elsevier
Biologic scaffold materials composed of mammalian extracellular matrix are commonly used
in regenerative medicine and in surgical procedures for the reconstruction of numerous
tissue and organs. These biologic materials are typically allogeneic or xenogeneic in origin
and are derived from tissues such as small intestine, urinary bladder, dermis, and
pericardium. The innate and acquired host immune response to these biologic materials and
the effect of the immune response upon downstream remodeling events has been largely …
Biologic scaffold materials composed of mammalian extracellular matrix are commonly used in regenerative medicine and in surgical procedures for the reconstruction of numerous tissue and organs. These biologic materials are typically allogeneic or xenogeneic in origin and are derived from tissues such as small intestine, urinary bladder, dermis, and pericardium. The innate and acquired host immune response to these biologic materials and the effect of the immune response upon downstream remodeling events has been largely unexplored. Variables that affect the host response include manufacturing processes, the rate of scaffold degradation, and the presence of cross species antigens. This manuscript provides an overview of studies that have evaluated the immune response to biologic scaffold materials and variables that affect this response.
Elsevier