[HTML][HTML] The role of protein kinase D in neurotensin secretion mediated by protein kinase C-α/-δ and Rho/Rho kinase
J Li, KL O'Connor, MR Hellmich, GH Greeley… - Journal of Biological …, 2004 - ASBMB
Neurotensin (NT) is a gut peptide that plays an important role in gastrointestinal (GI)
secretion, motility, and growth as well as the proliferation of NT receptor positive cancers.
Secretion of NT is regulated by phorbol ester-sensitive protein kinase C (PKC) isoforms-α
and-δ and may involve protein kinase D (PKD). The purpose of our present study was:(i) to
define the role of PKD in NT release from BON endocrine cells and (ii) to delineate the
upstream signaling mechanisms mediating this effect. Here, we demonstrate that small …
secretion, motility, and growth as well as the proliferation of NT receptor positive cancers.
Secretion of NT is regulated by phorbol ester-sensitive protein kinase C (PKC) isoforms-α
and-δ and may involve protein kinase D (PKD). The purpose of our present study was:(i) to
define the role of PKD in NT release from BON endocrine cells and (ii) to delineate the
upstream signaling mechanisms mediating this effect. Here, we demonstrate that small …