[HTML][HTML] Glucose-stimulated Cdc42 signaling is essential for the second phase of insulin secretion
Z Wang, E Oh, DC Thurmond - Journal of Biological Chemistry, 2007 - ASBMB
The small Rho family GTPases Cdc42 and Rac1 have each been shown to function in
insulin exocytosis and are presumed to function in actin remodeling and insulin granule
mobilization. However, whether either GTPase is required for the mobilization phase of
insulin release (second phase) and are linked in a common signaling pathway has
remained unknown. Here we demonstrate that small interfering RNA-mediated depletion of
Cdc42 from isolated islets results in the selective loss of secondphase insulin release …
insulin exocytosis and are presumed to function in actin remodeling and insulin granule
mobilization. However, whether either GTPase is required for the mobilization phase of
insulin release (second phase) and are linked in a common signaling pathway has
remained unknown. Here we demonstrate that small interfering RNA-mediated depletion of
Cdc42 from isolated islets results in the selective loss of secondphase insulin release …