[HTML][HTML] Inhibition of AP-1 by the glucocorticoid-inducible protein GILZ
PR Mittelstadt, JD Ashwell - Journal of Biological Chemistry, 2001 - ASBMB
The immunosuppressive effects of glucocorticoids arise largely by inhibition of cytokine
gene expression, which has been ascribed to interference between the glucocorticoid
receptor and transcription factors such as AP-1 and NF-κB as well as by competition for
common coactivators. Here we show that glucocorticoid-induced inhibition of interleukin-2
mRNA expression in activated normal T cells required new protein synthesis, suggesting
that this phenomenon is secondary to expression of glucocorticoid-regulated genes. One of …
gene expression, which has been ascribed to interference between the glucocorticoid
receptor and transcription factors such as AP-1 and NF-κB as well as by competition for
common coactivators. Here we show that glucocorticoid-induced inhibition of interleukin-2
mRNA expression in activated normal T cells required new protein synthesis, suggesting
that this phenomenon is secondary to expression of glucocorticoid-regulated genes. One of …