Evidence of extraordinary growth in the progressive enlargement of renal cysts

JJ Grantham, LT Cook, LH Wetzel… - Clinical Journal of the …, 2010 - journals.lww.com
Background and objectives: In autosomal dominant polycystic kidney disease, cysts derived
from tubules are detected at birth by ultrasound (threshold for detection> 7.0 mm); thus, fetal
cyst growth rates must exceed 2300%/yr. In adults, the combined renal cyst component
enlarges at approximately 12%/yr by growth of individual cysts. To explore this discrepancy,
the growth rates of individual cysts were determined in adult polycystic kidneys.