Vasopressin directly regulates cyst growth in polycystic kidney disease
X Wang, Y Wu, CJ Ward, PC Harris… - Journal of the American …, 2008 - journals.lww.com
The polycystic kidney diseases (PKD) are a group of genetic disorders causing renal failure
and death from infancy to adulthood. Arginine vasopressin (AVP) V2 receptor antagonists
inhibit cystogenesis in animal models of cystic kidney diseases, presumably by
downregulating cAMP signaling, cell proliferation, and chloride-driven fluid secretion. For
confirmation that the protective effect of these drugs is due to antagonism of AVP, PCK
(Pkhd1−/−) and Brattleboro (AVP−/−) rats were crossed to generate rats with PKD and …
and death from infancy to adulthood. Arginine vasopressin (AVP) V2 receptor antagonists
inhibit cystogenesis in animal models of cystic kidney diseases, presumably by
downregulating cAMP signaling, cell proliferation, and chloride-driven fluid secretion. For
confirmation that the protective effect of these drugs is due to antagonism of AVP, PCK
(Pkhd1−/−) and Brattleboro (AVP−/−) rats were crossed to generate rats with PKD and …