Development of polycystic kidney disease in juvenile cystic kidney mice: insights into pathogenesis, ciliary abnormalities, and common features with human disease
LA Smith, NO Bukanov, H Husson… - Journal of the …, 2006 - journals.lww.com
Significant progress in understanding the molecular mechanisms of polycystic kidney
disease (PKD) has been made in recent years. Translating this understanding into effective
therapeutics will require testing in animal models that closely resemble human PKD by
multiple parameters. Similar to autosomal dominant PKD, juvenile cystic kidney (jck) mice
develop cysts in multiple nephron segments, including cortical collecting ducts, distal
tubules, and loop of Henle. The jck mice display gender dimorphism in kidney disease …
disease (PKD) has been made in recent years. Translating this understanding into effective
therapeutics will require testing in animal models that closely resemble human PKD by
multiple parameters. Similar to autosomal dominant PKD, juvenile cystic kidney (jck) mice
develop cysts in multiple nephron segments, including cortical collecting ducts, distal
tubules, and loop of Henle. The jck mice display gender dimorphism in kidney disease …