[HTML][HTML] Calcium restriction allows cAMP activation of the B-Raf/ERK pathway, switching cells to a cAMP-dependent growth-stimulated phenotype
T Yamaguchi, DP Wallace, BS Magenheimer… - Journal of Biological …, 2004 - ASBMB
cAMP can be either mitogenic or anti-mitogenic, depending on the cell type. We
demonstrated previously that cAMP inhibited the proliferation of normal renal epithelial cells
and stimulated the proliferation of cells derived from the cysts of polycystic kidney disease
(PKD) patients. The protein products of the genes causing PKD, polycystin-1 and polycystin-
2, are thought to regulate intracellular calcium levels, suggesting that abnormal polycystin
function may affect calcium signaling and thus cause a switch to the cAMP growth-stimulated …
demonstrated previously that cAMP inhibited the proliferation of normal renal epithelial cells
and stimulated the proliferation of cells derived from the cysts of polycystic kidney disease
(PKD) patients. The protein products of the genes causing PKD, polycystin-1 and polycystin-
2, are thought to regulate intracellular calcium levels, suggesting that abnormal polycystin
function may affect calcium signaling and thus cause a switch to the cAMP growth-stimulated …