[HTML][HTML] At the crossroads of inflammation and cancer

H Clevers - Cell, 2004 - cell.com
Cell, 2004cell.com
Chronic inflammation and cancer are closely associated in the intestine. Anti-inflammatory
medication reduces intestinal neoplasia, while colorectal cancer incidence is increased in
ulcerative colitis. Cyclooxygenases are key to both diseases, yet the molecular basis of the
association remains incompletely understood. Two recent Cell (Greten et al., 2004; Rakoff-
Nahoum et al., 2004) papers illuminate roles of Toll-like receptors and the NF-κB pathway in
the control of epithelial homeostasis in health and disease.
Abstract
Chronic inflammation and cancer are closely associated in the intestine. Anti-inflammatory medication reduces intestinal neoplasia, while colorectal cancer incidence is increased in ulcerative colitis. Cyclooxygenases are key to both diseases, yet the molecular basis of the association remains incompletely understood. Two recent Cell (Greten et al., 2004; Rakoff-Nahoum et al., 2004) papers illuminate roles of Toll-like receptors and the NF-κB pathway in the control of epithelial homeostasis in health and disease.
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