Tpl2 kinase signal transduction in inflammation and cancer

M Vougioukalaki, DC Kanellis, K Gkouskou… - Cancer letters, 2011 - Elsevier
Cancer letters, 2011Elsevier
The activation of mitogen-activated protein kinases (MAPKs) is critically involved in
inflammatory and oncogenic events. Tumor progression locus 2 (Tpl2), also known as COT
and MAP3 kinase 8 (MAP3K8), is a serine-threonine kinase with an important physiological
role in tumor necrosis factor, interleukin-1, CD40, Toll-like receptor and G protein-coupled
receptor-mediated ERK MAPK signaling. Whilst the full characterization of the biochemical
events that lead to the activation of Tpl2 still represent a major challenge, genetic and …
The activation of mitogen-activated protein kinases (MAPKs) is critically involved in inflammatory and oncogenic events. Tumor progression locus 2 (Tpl2), also known as COT and MAP3 kinase 8 (MAP3K8), is a serine-threonine kinase with an important physiological role in tumor necrosis factor, interleukin-1, CD40, Toll-like receptor and G protein-coupled receptor-mediated ERK MAPK signaling. Whilst the full characterization of the biochemical events that lead to the activation of Tpl2 still represent a major challenge, genetic and molecular evidence has highlighted interesting interactions with the NF-κB network. Here, we provide an overview of the multifaceted functions of Tpl2 and the molecular mechanisms that govern its regulation.
Elsevier