SCART scavenger receptors identify a novel subset of adult γδ T cells

J Kisielow, M Kopf, K Karjalainen - The Journal of Immunology, 2008 - journals.aai.org
J Kisielow, M Kopf, K Karjalainen
The Journal of Immunology, 2008journals.aai.org
Although there has been great progress in the characterization of αβ T cell differentiation,
selection, and function, γδ T cells have remained poorly understood. One of the main
reasons for this is the lack of γδ T cell-specific surface markers other than the TCR chains
themselves. In this study we describe two novel surface receptors, SCART1 and SCART2.
SCARTs are related to CD5, CD6, and CD163 scavenger receptors but, unlike them, are
found primarily on developing and mature γδ T cells. Characterization of SCART2 positive …
Abstract
Although there has been great progress in the characterization of αβ T cell differentiation, selection, and function, γδ T cells have remained poorly understood. One of the main reasons for this is the lack of γδ T cell-specific surface markers other than the TCR chains themselves. In this study we describe two novel surface receptors, SCART1 and SCART2. SCARTs are related to CD5, CD6, and CD163 scavenger receptors but, unlike them, are found primarily on developing and mature γδ T cells. Characterization of SCART2 positive immature and peripheral γδ T cells suggests that they undergo lineage specification in the thymus and belong to a new IL-17-producing subset with distinct homing capabilities.
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