Pathogenesis of Escherichia coli O157: H7 strain 86-24 following oral infection of BALB/c mice with an intact commensal flora

KL Mohawk, AR Melton-Celsa, T Zangari… - Microbial …, 2010 - Elsevier
Escherichia coli O157: H7 is a food-borne pathogen that can cause hemorrhagic colitis and,
occasionally, hemolytic uremic syndrome, a sequela of infection that can result in renal
failure and death. Here we sought to model the pathogenesis of orally-administered E. coli
O157: H7 in BALB/c mice with an intact intestinal flora. First, we defined the optimal dose
that permitted sustained fecal shedding of E. coli O157: H7 over 7 days (∼ 109 colony
forming units). Next, we monitored the load of E. coli O157: H7 in intestinal sections over …