A genetic locus of enterocyte effacement conserved among diverse enterobacterial pathogens.
TK McDaniel, KG Jarvis… - Proceedings of the …, 1995 - National Acad Sciences
TK McDaniel, KG Jarvis, MS Donnenberg, JB Kaper
Proceedings of the National Academy of Sciences, 1995•National Acad SciencesEnteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli O157: H7 are
intestinal pathogens that profoundly damage the microvilli and subapical cytoskeleton of
epithelial cells. Here we report finding in EPEC a 35-kbp locus containing several regions
implicated in formation of these lesions. DNA probes throughout this locus hybridize to E.
coli O157: H7 and other pathogens of three genera that cause similar lesions but do not
hybridize to avirulent members of the same species. The EPEC locus and a different …
intestinal pathogens that profoundly damage the microvilli and subapical cytoskeleton of
epithelial cells. Here we report finding in EPEC a 35-kbp locus containing several regions
implicated in formation of these lesions. DNA probes throughout this locus hybridize to E.
coli O157: H7 and other pathogens of three genera that cause similar lesions but do not
hybridize to avirulent members of the same species. The EPEC locus and a different …
Enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli O157:H7 are intestinal pathogens that profoundly damage the microvilli and subapical cytoskeleton of epithelial cells. Here we report finding in EPEC a 35-kbp locus containing several regions implicated in formation of these lesions. DNA probes throughout this locus hybridize to E. coli O157:H7 and other pathogens of three genera that cause similar lesions but do not hybridize to avirulent members of the same species. The EPEC locus and a different virulence locus of uropathogenic E. coli insert into the E. coli chromosome at the identical site and share highly similar sequences near the point of insertion.
National Acad Sciences