miR-21, miR-210, miR-34a, and miR-146a/b are up-regulated in human atherosclerotic plaques in the Tampere Vascular Study
E Raitoharju, LP Lyytikäinen, M Levula, N Oksala… - Atherosclerosis, 2011 - Elsevier
OBJECTIVE: MicroRNAs are small non-coding RNAs that inversely regulate their target
gene expression. The whole miRNA profile of human atherosclerotic plaques has not been
studied previously. The aim of this study was to investigate the miRNA expression profile in
human atherosclerotic plaques as compared to non-atherosclerotic left internal thoracic
arteries (LITA), and to connect this expression to the processes in atherosclerosis.
METHODS: The miRNA expression profiles of six LITAs and 12 atherosclerotic plaques …
gene expression. The whole miRNA profile of human atherosclerotic plaques has not been
studied previously. The aim of this study was to investigate the miRNA expression profile in
human atherosclerotic plaques as compared to non-atherosclerotic left internal thoracic
arteries (LITA), and to connect this expression to the processes in atherosclerosis.
METHODS: The miRNA expression profiles of six LITAs and 12 atherosclerotic plaques …