Mutation in the gene responsible for cystic fibrosis and predisposition to chronic rhinosinusitis in the general population
XJ Wang, B Moylan, DA Leopold, J Kim… - Jama, 2000 - jamanetwork.com
ContextChronic rhinosinusitis (CRS) is a common condition in the US general population,
yet little is known about its underlying molecular cause. Chronic rhinosinusitis is a consistent
feature of the autosomal recessive disorder cystic fibrosis (CF). ObjectiveTo determine
whether mutations in the cystic fibrosis transmembrane regulator (CFTR) gene, which is
responsible for CF, predispose to CRS. DesignCase-control study conducted from 1996 to
1999 in which the DNA of CRS patients and controls was typed for 16 mutations that account …
yet little is known about its underlying molecular cause. Chronic rhinosinusitis is a consistent
feature of the autosomal recessive disorder cystic fibrosis (CF). ObjectiveTo determine
whether mutations in the cystic fibrosis transmembrane regulator (CFTR) gene, which is
responsible for CF, predispose to CRS. DesignCase-control study conducted from 1996 to
1999 in which the DNA of CRS patients and controls was typed for 16 mutations that account …