[HTML][HTML] Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate
EL Laviad, L Albee, I Pankova-Kholmyansky… - Journal of Biological …, 2008 - ASBMB
Ceramide is an important lipid signaling molecule and a key intermediate in sphingolipid
biosynthesis. Recent studies have implied a previously unappreciated role for the ceramide
N-acyl chain length, inasmuch as ceramides containing specific fatty acids appear to play
defined roles in cell physiology. The discovery of a family of mammalian ceramide synthases
(CerS), each of which utilizes a restricted subset of acyl-CoAs for ceramide synthesis,
strengthens this notion. We now report the characterization of mammalian CerS2. qPCR …
biosynthesis. Recent studies have implied a previously unappreciated role for the ceramide
N-acyl chain length, inasmuch as ceramides containing specific fatty acids appear to play
defined roles in cell physiology. The discovery of a family of mammalian ceramide synthases
(CerS), each of which utilizes a restricted subset of acyl-CoAs for ceramide synthesis,
strengthens this notion. We now report the characterization of mammalian CerS2. qPCR …