FN18-Crm9 immunotoxin promotes tolerance in primate renal Allografts1
Transplantation, 1997•journals.lww.com
Background. Transplant tolerance, rather than immunity, may be favored in the setting of a
lower mature lymphoid mass in the recipient induced by anti-T cell agents. A novel
immunosuppressive agent, FN18-CRM9, known to specifically kill T cells with great potency,
was evaluated in a transplant model. Methods. In order to ablate recipient T cells, the
immunotoxin FN18-CRM9 was administered to rhesus monkey recipients of MHC-
mismatched renal allografts. Donor lymphocytes were injected intrathymically into some …
lower mature lymphoid mass in the recipient induced by anti-T cell agents. A novel
immunosuppressive agent, FN18-CRM9, known to specifically kill T cells with great potency,
was evaluated in a transplant model. Methods. In order to ablate recipient T cells, the
immunotoxin FN18-CRM9 was administered to rhesus monkey recipients of MHC-
mismatched renal allografts. Donor lymphocytes were injected intrathymically into some …
Abstract
Background.
Transplant tolerance, rather than immunity, may be favored in the setting of a lower mature lymphoid mass in the recipient induced by anti-T cell agents. A novel immunosuppressive agent, FN18-CRM9, known to specifically kill T cells with great potency, was evaluated in a transplant model.
Methods.
In order to ablate recipient T cells, the immunotoxin FN18-CRM9 was administered to rhesus monkey recipients of MHC-mismatched renal allografts. Donor lymphocytes were injected intrathymically into some animals.
Results.
All monkeys with T-cell depletion by immunotoxin had prolonged allograft survival, and tolerance confirmed by skin grafting has been confirmed in five of six long-surviving recipients.
Conclusions.
In this clinically relevant model, profound but transient T-cell depletion by a single agent substantially promotes tolerance.
Lippincott Williams & Wilkins