[HTML][HTML] Biopharmaceutical aspects of FK-506
R Venkataramanan, VS Watty, MA Zemaitis… - Transplantation …, 1987 - ncbi.nlm.nih.gov
R Venkataramanan, VS Watty, MA Zemaitis, AT Sanghvi, GJ Burckart, H Seltman, S Todo…
Transplantation proceedings, 1987•ncbi.nlm.nih.govFK-506 (FK) is a novel immunosuppressant isolated from Streptomyces tsukubaensis (Fig
1). It is nearly 500 times more potent than cyclosporine (CyA) in inhibiting lymphocyte
proliferation in mixed lymphocyte cultures. 1 In vivo, it significantly prolongs the graft survival
in rats receiving heterotopic heart transplants2 and dogs receiving renal3 or liver
transplants. 4
1). It is nearly 500 times more potent than cyclosporine (CyA) in inhibiting lymphocyte
proliferation in mixed lymphocyte cultures. 1 In vivo, it significantly prolongs the graft survival
in rats receiving heterotopic heart transplants2 and dogs receiving renal3 or liver
transplants. 4
FK-506 (FK) is a novel immunosuppressant isolated from Streptomyces tsukubaensis (Fig 1). It is nearly 500 times more potent than cyclosporine (CyA) in inhibiting lymphocyte proliferation in mixed lymphocyte cultures. 1 In vivo, it significantly prolongs the graft survival in rats receiving heterotopic heart transplants2 and dogs receiving renal3 or liver transplants. 4
ncbi.nlm.nih.gov